Upregulation of Neurodevelopmental Genes During Scarless Healing

Scarless fetal skin wound healing is a paradigm for ideal skin repair and is dependent on peripheral nerve function. To further explore neurogenic mechanisms influence on the scarless skin repair, fetal rats were wounded on gestational days 16 (E16; n = 24) and 18 (E18; n = 8) and wounds were harvested at 1 and 3 days after injury. Unwounded skin at identical gestational age was used for control comparison. The scarless E16 and scarring E18...