Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness
Abstract
Allergic asthma is a complex syndrome characterized by airway obstruction, airway inflammation and airway hyper-responsiveness (AHR). Using a mouse model of allergen-induced AHR, we previously demonstrated that CD8-deficient mice develop significantly lower AHR, eosinophilic inflammation and interleukin (IL)-13 levels in bronchoalveolar lavage fluid compared with wild-type mice. These responses were restored by adoptive transfer of...
Paper Details
Title
Effector CD8+ T cells mediate inflammation and airway hyper-responsiveness
Published Date
Jul 18, 2004
Journal
Volume
10
Issue
8
Pages
865 - 869
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Notes
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