Design Optimization of a Novel pMDI Actuator for Systemic Drug Delivery
Abstract
Pressurized metered dose inhalers (pMDIs) are the most widely prescribed and economical respiratory drug delivery systems. Conventional pMDI actuators-those based on "two-orifice-and-sump" designs-produce an aerosol with a reasonable respirable fraction, but with high aerosol velocity. The latter is responsible for high oropharyngeal deposition, and consequently low drug delivery efficiency. Kos' pMDI technology is based on a proprietary vortex...
Paper Details
Title
Design Optimization of a Novel pMDI Actuator for Systemic Drug Delivery
Published Date
Dec 1, 2007
Journal
Volume
20
Issue
4
Pages
460 - 474
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