Novel action of activin and bone morphogenetic protein in regulating aldosterone production by human adrenocortical cells.
Abstract
We have uncovered a functional bone morphogenetic protein (BMP) and activin system complete with ligands (BMP-6 and activin betaA/betaB), receptors (activin receptor-like kinase receptors 2, 3, and 4; activin type-II receptor; and BMP type-II receptor), and the binding protein follistatin in the human adrenocortical cell line H295R. Administration of activin and BMP-6 to cultures of H295R cells caused concentration-responsive increases in...
Paper Details
Title
Novel action of activin and bone morphogenetic protein in regulating aldosterone production by human adrenocortical cells.
Published Date
Feb 1, 2004
Journal
Volume
145
Issue
2
Pages
639 - 649
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Notes
History