Determination of the hydrophobicity of organic compounds measured as logPo/w through a new chromatographic method

Volume: 1217, Issue: 18, Pages: 3026 - 3037
Published: Apr 1, 2010
Abstract
A new chromatographic method to determine the octanol-water partition coefficient (logP(o/w)) of organic substances is proposed in this paper. This method is based on a previously reported model that relates the retention factor in reversed-phase liquid chromatography with solute (p), mobile phase (P(m)(N)) and stationary phase (P(s)(N)) polarity parameters: logk=(logk)(0)+p(P(m)(N)-P(s)(N)). P(m)(N) values are calculated through expressions...
Paper Details
Title
Determination of the hydrophobicity of organic compounds measured as logPo/w through a new chromatographic method
Published Date
Apr 1, 2010
Volume
1217
Issue
18
Pages
3026 - 3037
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