Substrate Rigidity Regulates the Formation and Maintenance of Tissues
Abstract
The ability of cells to form tissues represents one of the most fundamental issues in biology. However, it is unclear what triggers cells to adhere to one another in tissues and to migrate once a piece of tissue is planted on culture surfaces. Using substrates of identical chemical composition but different flexibility, we show that this process is controlled by substrate rigidity: on stiff substrates, cells migrate away from one another and...
Paper Details
Title
Substrate Rigidity Regulates the Formation and Maintenance of Tissues
Published Date
Mar 1, 2006
Journal
Volume
90
Issue
6
Pages
2213 - 2220
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