Negative electro-mechanical windows are required for drug-induced Torsades de Pointes in the anesthetized guinea pig
Volume: 66, Issue: 2, Pages: 125 - 134
Published: Sep 1, 2012
Abstract
Assessment of the propensity of novel drugs to cause proarrhythmia is essential in the drug development process. It is increasingly recognized, however, that QT prolongation alone is an imperfect surrogate marker for Torsades de Pointes (TdP) arrhythmia prediction. In the present study we investigated the behavior of a novel surrogate marker for TdP, the electro-mechanical (E-M) window, prior to triggering of TdP episodes with sympathetic...
Paper Details
Title
Negative electro-mechanical windows are required for drug-induced Torsades de Pointes in the anesthetized guinea pig
Published Date
Sep 1, 2012
Volume
66
Issue
2
Pages
125 - 134
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