The ShcA SH2 domain engages a 14-3-3/PI3′K signaling complex and promotes breast cancer cell survival
Abstract
The ShcA adapter protein transmits activating signals downstream of receptor and cytoplasmic tyrosine kinases through the establishment of phosphotyrosine-dependent complexes. In this regard, ShcA possesses both a phosphotyrosine-binding domain (PTB) and Src homology 2 domain (SH2), which bind phosphotyrosine residues in a sequence-specific manner. Although the majority of receptor tyrosine kinases expressed in breast cancer cells bind the PTB...
Paper Details
Title
The ShcA SH2 domain engages a 14-3-3/PI3′K signaling complex and promotes breast cancer cell survival
Published Date
Jan 30, 2012
Journal
Volume
31
Issue
48
Pages
5038 - 5044
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