Effects of early versus delayed terlipressin infusion on hemodynamics and catecholamine requirements in ovine septic shock

Terlipressin (TP) is increasingly used in catecholamine-dependent septic shock. Whereas recent data suggest advantages of continuous infusion over repetitive bolus infusion, the optimal time of TP initiation remains unclear. The present study was designed as a prospective laboratory experiment to compare the impact of early versus delayed TP infusion on key hemodynamic variables, as well as fluid and catecholamine requirements in ovine septic...