Current ADC Linker Chemistry
Abstract
The list of ADCs in the clinic continues to grow, bolstered by the success of first two marketed ADCs: ADCETRIS® and Kadcyla®. Currently, there are 40 ADCs in various phases of clinical development. However, only 34 of these have published their structures. Of the 34 disclosed structures, 24 of them use a linkage to the thiol of cysteines on the monoclonal antibody. The remaining 10 candidates utilize chemistry to surface lysines of the...
Paper Details
Title
Current ADC Linker Chemistry
Published Date
Mar 11, 2015
Journal
Volume
32
Issue
11
Pages
3526 - 3540
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History