Engineered Human Skin Fabricated Using Electrospun Collagen–PCL Blends: Morphogenesis and Mechanical Properties

Engineered human skin is commonly fabricated using collagen scaffolds that often have poor mechanical properties. To improve the strength of collagen-based scaffolds, poly(caprolactone) (PCL) was blended with collagen and formed into submicron fibers using electrospinning. At concentrations < 10% PCL (MPCL/[MCollagen + MPCL] × 100), the PCL component was evenly distributed within the collagen matrix. Increasing the PCL component to 30% caused...