Angiostatic activity of the antitumor cytokine interleukin-21
Abstract
Interleukin-21 (IL-21) is a recently described immunoregulatory cytokine. It has been identified as a very potent immunotherapeutic agent in several cancer types in animal models, and clinical studies are ongoing. IL-21 belongs to the type I cytokine family of which other members, ie, IL-2, IL-15, and IL-4, have been shown to exert activities on vascular endothelial cells (ECs). We hypothesized that IL-21, in addition to inducing the antitumor...
Paper Details
Title
Angiostatic activity of the antitumor cytokine interleukin-21
Published Date
Dec 15, 2008
Journal
Volume
112
Issue
13
Pages
4940 - 4947
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