Goodpastureʼs disease: molecular architecture of the autoantigen provides clues to etiology and pathogenesis
Volume: 20, Issue: 3, Pages: 290 - 296
Published: May 1, 2011
Abstract
Purpose of review Goodpasture's disease is an autoimmune disorder characterized by the deposition of pathogenic autoantibodies in basement membranes of kidney and lung, which induces rapidly progressive glomerulonephritis and pulmonary hemorrhage. The target antigen is the α3NC1 domain of collagen IV, which is expressed in target organs as an α345 network. Recent studies of specificity and epitopes of Goodpasture's autoantibodies and discovery...
Paper Details
Title
Goodpastureʼs disease: molecular architecture of the autoantigen provides clues to etiology and pathogenesis
Published Date
May 1, 2011
Volume
20
Issue
3
Pages
290 - 296
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