TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.

Cell64.50
Volume: 127, Issue: 6, Pages: 1123 - 1135
Published: Dec 15, 2006
Abstract
In type 1 diabetes, T cell-mediated death of pancreatic beta cells produces insulin deficiency. However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas remains unclear. We report that TRPV1(+) pancreatic sensory neurons control islet inflammation and insulin resistance. Eliminating these neurons in diabetes-prone NOD mice prevents insulitis and diabetes, despite systemic persistence of pathogenic T cell pools....
Paper Details
Title
TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.
Published Date
Dec 15, 2006
Journal
Volume
127
Issue
6
Pages
1123 - 1135
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