Estrogen receptor α and β heterodimers exert unique effects on estrogen- and tamoxifen- dependent gene expression in human U2OS osteosarcoma cells

Volume: 19, Issue: 6, Pages: 1555 - 1568
Published: Jun 1, 2005
Abstract
The 17beta-estradiol (E2) receptor isoforms [estrogen receptor (ER) alpha and ERbeta] bind E2 and selective ER modulators (SERMs) as homodimers (alpha/alpha or beta/beta) or heterodimers (alpha/beta) to regulate gene expression. Although recent studies have shown that ER homodimers regulate unique sets of E2-responsive genes, little information exists regarding the transcriptional actions of the ERalpha/beta heterodimer. This paper describes the...
Paper Details
Title
Estrogen receptor α and β heterodimers exert unique effects on estrogen- and tamoxifen- dependent gene expression in human U2OS osteosarcoma cells
Published Date
Jun 1, 2005
Volume
19
Issue
6
Pages
1555 - 1568
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