Ligand-targeted therapeutics in anticancer therapy

Volume: 2, Issue: 10, Pages: 750 - 763
Published: Oct 1, 2002
Abstract
Cytotoxic chemotherapy or radiotherapy of cancer is limited by serious, sometimes life-threatening, side effects that arise from toxicities to sensitive normal cells because the therapies are not selective for malignant cells. So how can selectivity be improved? One strategy is to couple the therapeutics to antibodies or other ligands that recognize tumour-associated antigens. This increases the exposure of the malignant cells, and reduces the...
Paper Details
Title
Ligand-targeted therapeutics in anticancer therapy
Published Date
Oct 1, 2002
Volume
2
Issue
10
Pages
750 - 763
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