Indium-111 pentetreotide uptake within cerebellar hemangioblastoma in von Hippel-lindau syndrome.

Published on Apr 1, 2008in Clinical Nuclear Medicine6.587
· DOI :10.1097/RLU.0B013E3181662BF9
Fahmid U. Chowdhury18
Estimated H-index: 18
,
Andrew Scarsbrook29
Estimated H-index: 29
Sources
Abstract
Abstract:A 38-year-old woman with known von Hippel-Lindau syndrome underwent In-111 pentetreotide (OctreoScan) scintigraphy to evaluate a suspected pancreatic neuroendocrine tumor. The patient had undergone surgical resection of a left adrenal pheochromocytoma and a large right cerebellar hemangiobl
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#1Christopher A. Friedrich (UPenn: University of Pennsylvania)H-Index: 5
Von Hippel-Lindau (VHL) syndrome (OMIM 193300) is an autosomal dominant disorder caused by deletions or mutations in a tumor suppressor gene mapped to human chromosome 3p25. It is characterized clinically by vascular tumors, including retinal and central nervous system hemangioblastomas (cerebellar, spinal, and brain stem). Hemangioblastomas are benign and do not metastasize. Other features include cysts of the kidneys, liver, and pancreas. Clear cell renal cell carcinoma occurs in up to 70% of ...
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The somatostatin analogue [111In-DTPA-d-Phe1]-octreotide (111In-octreotide) allows scintigraphic visualization of somatostatin receptor-expressing tissue. While it is well known that a large variety of tissues express somatostatin receptors and 111In-octreotide scintigraphy has a clearly defined role in various neuroendocrine diseases, the clinical value of 111In-octreotide scintigraphy in brain tumours is still under clinical investigation. In 124 patients with 141 brain lesions (63 meningiomas...
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von Hippel-Lindau (VHL) disease is an autosomal dominant disorder that causes retinal hemangioblastomas, hemangioblastomas of the central nervous system, endolymphatic sac tumors, renal cell carcinomas, pancreatic cysts and tumors, pheochromocytomas, and epididymal cystadenomas, among other less common manifestations. Although this entity has been recognized for almost 70 years, recent developments in the genetics and imaging of VHL disease have greatly improved understanding of the disease and ...
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Various tumours, classically specified as either neuroendocrine or non-neuroendocrine, contain high numbers of somatostatin receptors, which enable in vivo localization of the primary tumour and its metastases by scintigraphy with the radiolabelled somatostatin analogue octreotide. In addition granulomas and autoimmune processes can be visualized because of local accumulation of somatostatin receptor-positive activated mononuclear leucocytes. In many instances a positive scintigram predicts a fa...
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Hippel-Lindau disease is an auto-somal-dominant disorder characterized by tumors arising from the central nervous system and abdominal viscera. Because of its progressive nature, frequent multisystem radiologic evaluation of affected persons and family members at risk is desirable for early detection and treatment. During a 2-year study, magnetic resonance (MR) imaging of the head, spine, and abdomen was used for screening and follow-up in 26 members of nine families with the disease. In additio...
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AbstractA 35-year-old man with clinical suspicion of adrenal pheochromocytoma was evaluated using 68Ga DOTANOC PET/CT. PET/CT demonstrated 68Ga DOTANOC–avid right adrenal mass and cerebellar lesion, raising the suspicion of adrenal pheochromocytoma with cerebellar hemangioblastoma suggesting von Hip
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