Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion.
Abstract
Peripheral neuropathy is a common adverse effect of paclitaxel treatment. To analyze the contribution of transient receptor potential vanilloid 1 (TRPV1) in the development of paclitaxel-induced thermal hyperalgesia, TRPV1 expression in the rat dorsal root ganglion (DRG) was analyzed after paclitaxel treatment. Behavioral assessment using the tail-flick test showed that intraperitoneal administration of 2 and 4 mg/kg paclitaxel induced thermal...
Paper Details
Title
Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion.
Published Date
Jun 1, 2013
Journal
Volume
154
Issue
6
Pages
882 - 889
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