Targeting DNA topoisomerase II in cancer chemotherapy

Volume: 9, Issue: 5, Pages: 338 - 350
Published: May 1, 2009
Abstract
Recent molecular studies have expanded the biological contexts in which topoisomerase II (TOP2) has crucial functions, including DNA replication, transcription and chromosome segregation. Although the biological functions of TOP2 are important for ensuring genomic integrity, the ability to interfere with TOP2 and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. The molecular tools that have allowed an...
Paper Details
Title
Targeting DNA topoisomerase II in cancer chemotherapy
Published Date
May 1, 2009
Volume
9
Issue
5
Pages
338 - 350
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