Cytotoxic effects of surface-modified quantum dots on neuron-like PC12 cells cultured inside microfluidic devices

This paper describes the cytotoxic effects of surface-modified quantum dots (QDs) on neuronlike PC12 cells under localized exposure conditions. PC12 cells were cultured and differentiated on a two-compartment microfluidic neuronal device with the aim of preferentially isolating axons from their cell bodies and thus providing localized exposure of cell bodies or axons to QDs. In addition, we used two distinct ligands for surface modification of...