Glucose-regulated Glucagon Secretion Requires Insulin Receptor Expression in Pancreatic α-Cells

Volume: 280, Issue: 39, Pages: 33487 - 33496
Published: Sep 30, 2005
Abstract
The insulin receptor (IR) and its signaling appear to be essential for insulin secretion from pancreatic beta-cells. However, much less is known about the role of the IR in alpha-cells. To assess the role of the IR in glucagon and insulin secretion, we engineered adeno-viruses for high efficiency small interference RNA (siRNA)-IR expression in isolated mouse pancreatic islets and lentiviruses for siRNA-IR expression in pancreatic alpha- and...
Paper Details
Title
Glucose-regulated Glucagon Secretion Requires Insulin Receptor Expression in Pancreatic α-Cells
Published Date
Sep 30, 2005
Volume
280
Issue
39
Pages
33487 - 33496
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