Anti-leishmanial activity of betulin derivatives
Abstract
Leishmanicidal activity of 24 derivatives of naturally occurring and abundant triterpenes belonging to the lupane series, betulin, betulinic acid and betulonic acid, is described in this study. The easily modified positions of the lupane skeleton, the hydroxy groups of C-3 and C-28, as well as the carbon–carbon double bond C-20–C-29 were used as a starting point to prepare a library of triterpenoid derivatives for bioactivity studies. The...
Paper Details
Title
Anti-leishmanial activity of betulin derivatives
Published Date
Feb 5, 2010
Journal
Volume
63
Issue
3
Pages
123 - 126
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