Mast cell–dependent migration of effector CD8+ T cells through production of leukotriene B4
Abstract
Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known. Here we report that activated mast cells induced chemotaxis of effector, but not central memory, CD8+ T cells through production of leukotriene B4 (LTB4). These studies...
Paper Details
Title
Mast cell–dependent migration of effector CD8+ T cells through production of leukotriene B4
Published Date
Aug 31, 2003
Journal
Volume
4
Issue
10
Pages
974 - 981
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