Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33

BackgroundAsthma in a mouse model spontaneously resolves after cessation of allergen exposure. We developed a mouse model in which asthma features persisted for 6 months after cessation of allergen exposure.ObjectiveWe sought to elucidate factors contributing to the persistence of asthma.MethodsWe used a combination of immunologic, genetic, microarray, and pharmacologic approaches to dissect the mechanism of asthma persistence.ResultsElimination...