Membranous nephropathy: an IgG4-mediated disease
Abstract
Membranous nephropathy is characterised by the deposition of immunoglobulin, predominantly of the IgG4 subclass, along the epithelial surface of the glomerular-basement membrane. Current models of pathogenesis usually assume in-situ immune-complex formation involving an as yet uncharacterised fixed glomerular antigen. I argue that the properties of IgG4 (inability to fix complement and therefore impaired clearance of IgG4-containing complexes;...
Paper Details
Title
Membranous nephropathy: an IgG4-mediated disease
Published Date
Feb 1, 1998
Journal
Volume
351
Issue
9103
Pages
670 - 671
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Notes
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