Antiproliferative effects of formononetin on human colorectal cancer via suppressing cell growth in vitro and in vivo

Formononetin (FT) is a natural phytoestrogen isolated from red clover (Trifolium pratense L.). Growing evidences indicate that FT-mediated cell arrest in cancers in vitro. However, detailed investigations on colorectal cancer by FT remain limited. In this study, we aimed to explore the potential benefits of FT and discuss the underlying mechanisms. FT-administered human colorectal cancer cells (RKO cell line) were subjected to testing the...