The Relationship of Macular Microcirculation to Visual Acuity in Diabetic Patients

Published on May 1, 1995in Archives of Ophthalmology
· DOI :10.1001/ARCHOPHT.1995.01100050078034
Oliver Arend36
Estimated H-index: 36
(RWTH Aachen University),
Sebastian Wolf73
Estimated H-index: 73
(RWTH Aachen University)
+ 1 AuthorsMartin Reim26
Estimated H-index: 26
(RWTH Aachen University)
Sources
Abstract
Objective: To assess the perifoveal microcirculation in diabetic maculopathy without clinically significant macular edema and its relationship to visual acuity. Design: Prospective analysis. Setting: A teaching hospital. Patients: Fifteen patients with impaired visual acuity of 20/50 or worse, a diabetic control population with unaffected visual acuity (matched age, gender, retinopathy stage), and 52 healthy controls were enrolled. Interventions: Study consisted of video-fluorescein angiography with image analyses and hemoglobin A1cmeasurements. Main Outcome Measures: Macular capillary blood velocity, capillary density (perifoveal intercapillary area), and foveal avascular zone. Results: The capillary blood velocity was significantly reduced in both diabetic groups (P Conclusions: Capillary blood velocity remained unchanged regardless of presence of visual impairment, whereas foveal avascular zone and perifoveal intercapillary area indicated ischemia. This may help in defining a critical hypoxic threshold for visual loss and identifying the presence of an ischemic diabetic maculopathy.
📖 Papers frequently viewed together
References34
Newest
#1Bennett Ag (Northampton Community College)H-Index: 1
#2Alicja R. Rudnicka (Northampton Community College)H-Index: 60
Last. David F Edgar (Northampton Community College)H-Index: 21
view all 3 authors...
Littmann's formula relating the size of a retinal feature to its measured image size on a telecentric fundus camera film is widely used. It requires only the corneal radius, ametropia, and Littmann's factor q obtained from nomograms or tables. These procedures are here computerized for practitioners' convenience. Basic optical principles are discussed, showing q to be a constant fraction of the theoretical ocular dimension k′, the distance from the eye's second principal point to the retina. If ...
Source
#1Sebastian WolfH-Index: 73
#2Oliver ArendH-Index: 36
Last. M. ReimH-Index: 18
view all 5 authors...
Arterial hypertension is known to be an important risk factor for cerebral and cardiovascular disease. Previous studies in rats have demonstrated that changes in both capillary density and vessel diameter may contribute to increased vascular resistance in hypertension. In vivo studies of human subjects with essential hypertension revealed a reduction in the number of arterioles in the skin and conjunctiva; no other in vivo data are available from other tissues. By means of a new imaging techniqu...
Source
#1Oliver Arend (RWTH Aachen University)H-Index: 36
#2Sebastian Wolf (RWTH Aachen University)H-Index: 73
Last. Martin Reim (RWTH Aachen University)H-Index: 26
view all 7 authors...
Fluorescein angiograms were performed to evaluate perifoveal capillary blood velocities (v), capillary density (perifoveal intercapillary areas: PIA) and the foveal avascular zone (FAZ) by means of the scanning laser technique (SLO-101 Rodenstock). The angiograms were digitally stored and the data quantified off-line with an image analyzing system (IBAS). In the present study 46 patients with non-insulin-dependent diabetes mellitus (NIDDM) were examined and their data compared with that of 31 he...
Source
#1Yoshitaka Ohnishi (Kyushu University)H-Index: 14
#2Kimihiko Fujisawa (Kyushu University)H-Index: 18
Last. Hiroki Kojima (Kyushu University)H-Index: 1
view all 4 authors...
Using a scanning laser ophthalmoscope, we calculated the velocity of retinal blood flow in a juxtafoveolar capillary during the course of cystoid macular edema after partial central retinal vein occlusion in a 53-year-old woman. The mean velocity of the fluorescent dots in the macular capillary of the right eye with cystoid macular edema was 1.59 ± 0.08 mm/sec at the initial examination. Despite the systemic administration of indomethacin (75 mg/day for three weeks), best-corrected visual acuity...
Source
#1Ahmad M. Mansour (UTMB: University of Texas Medical Branch)H-Index: 35
#2Andrew P. SchachatH-Index: 46
Last. Robert HaymondH-Index: 1
view all 4 authors...
AbstractThe foveal avascular zone was measured angiographically in 144 subjects with diabetic retinopathy and 27 control subjects. Statistical significance was defined as P < 0.01. Quantitatively, the foveal avascular zone was significantly smaller in control eyes (median = 0.405 mm2) than in eyes w
Source
The oxygen tension in the preretinal vitreous cavity was measured in human patients undergoing vitreous operations for proliferative diabetic retinopathy. The oxygen tension was significantly higher (P = .004) over areas of retina that had been treated with panretinal photocoagulation than it was over untreated areas in the same retina. This confirmed previous results in animals that showed that panretinal photocoagulation increases the inner retinal oxygen tension. We concluded that panretinal ...
Source
#1Bernd BertramH-Index: 15
#2Sebastian Wolf (RWTH Aachen University)H-Index: 73
Last. Martin ReimH-Index: 26
view all 8 authors...
Rheological parameters (hematocrit, plasma viscosity and red blood cell aggregation index), glycosylated hemoglobin (HbAlc) and retinal arteriovenous passagetime (A vP) were measured in 93 patients with type I diabetes. The stage of diabetic retinopathy was graded by means of ophthalmoscopy and video fluorescein angiography. The mean values of hematocrit (men 46 ± 4%, women 43 ± 3 %), RBC aggregation index (13,8 ± 3,8, normals: 14,6 ± 3,2) were equal to normals. Plasma viscosity (1,33 ± 0,09 mPa...
Source
#1Oliver Arend (RWTH Aachen University)H-Index: 36
#2Sebastian WolfH-Index: 73
Last. M. ReimH-Index: 18
view all 7 authors...
The new scanning laser technique allows one to quantify the retinal microcirculation. A digital image analysing system was used to study capillary blood flow velocities and morphological parameters of perifoveal intercapillary areas and foveal avascular zones in normal and diabetic subjects. Diabetic patients showed a significant reduction in capillary blood cell velocities in comparison with normal subjects. Perifoveal intercapillary areas and foveal avascular zones were significantly increased...
Source
#1Bernd Bertram (RWTH Aachen University)H-Index: 15
#2Sebastian WolfH-Index: 73
Last. M. ReimH-Index: 18
view all 6 authors...
Video fluorescein angiography was performed in 124 patients between 18 and 65 years of age (mean 35.0, SD 12.3 years) with juvenile-onset, insulin-dependent diabetes mellitus (type 1). The arm-retina time (ART) and the retinal arteriovenous passage time (AVP) were measured by means of a picture analysis system to quantify the retinal microcirculation. Glucose metabolism was assessed by the blood level of haemoglobin A1c. The ART 11.5, SD 3.4 s) was similar to that in normal persons (11.2, SD 3.3...
Source
#1S Schröder (UCSD: University of California, San Diego)H-Index: 1
#2Wulf PalinskiH-Index: 77
view all 3 authors...
Capillary occlusions are characteristic features of the early diabetic retinopathy and are presumed to initiate neovascularization. Activated leukocytes can cause microvascular occlusions and cell damage by release of cytotoxic products. To explore the role of leukocytes in capillary occlusion, nonperfusion, and neovascularization of diabetic retinopathy, a rat model was used, in which a diabetic state was induced by alloxan. Retina flat preparations were differentially stained for monocytes and...
Cited By106
Newest
#1Andreas BringmannH-Index: 62
#2Peter WiedemannH-Index: 2
Source
#1Patrick H. Le (UNC: University of North Carolina at Chapel Hill)H-Index: 3
#2Jason Zehden (UNC: University of North Carolina at Chapel Hill)
Last. Alice Yang Zhang (UNC: University of North Carolina at Chapel Hill)H-Index: 5
view all 3 authors...
PURPOSE OF REVIEW Ocular manifestations in patients with diabetes mellitus (DM) can present as microvascular changes. These microvascular changes can be challenging to identify on exams, and imaging technologies have commonly aided in the diagnosis and management of patients with DM. Optical coherence tomography angiography (OCTA) provides noninvasive image segmentation of various layers of the retina and choroid. Also, post-processing of images and associated quantitative measurements offer pot...
Source
#1Julian Lo (SFU: Simon Fraser University)H-Index: 4
#2Timothy Yu (SFU: Simon Fraser University)H-Index: 1
Last. Yali Jia (OHSU: Oregon Health & Science University)H-Index: 45
view all 11 authors...
Abstract null null Purpose null To evaluate the performance of a federated learning framework for deep neural network-based retinal microvasculature segmentation and referable diabetic retinopathy (RDR) classification using optical coherence tomography (OCT) and OCT angiography (OCTA). null null null Design null Retrospective analysis of clinical OCT and OCTA scans of control and diabetic patients. null null null Participants null The data used for microvasculature segmentation consisted of OCTA...
Source
Source
#1Fatma TaherH-Index: 12
#2Heba KandilH-Index: 5
Last. Ayman El-BazH-Index: 58
view all 9 authors...
Source
PURPOSE The objective of this study was to evaluate the vascular parameters of the retinal zones and the optic disc (OD) with the use of optical coherence tomography angiography (OCTA) in pediatric patients with type 1 diabetes mellitus (T1DM). METHODS This study enrolled 60 patients with T1DM without clinically detectable diabetic retinopathy (DR), along with 59 age-, gender-, and pubertal stage-matched controls. The ages of the participants in both groups were < 18 years. Retinal and OD measur...
Source
#1Marion R. Munk (University of Bern)H-Index: 15
#2Amir H. Kashani (Johns Hopkins University)H-Index: 27
Last. Meng Tian (University of Bern)H-Index: 7
view all 7 authors...
ABSTRACT Purpose To develop a consensus nomenclature for optical coherence tomography angiography (OCTA) findings in retinal vascular diseases. Design Online survey using Delphi Method Subjects, Participants and/or Controls Members of The Retina Society, European Society of Retina Specialists (EURETINA) and the Japanese Retina and Vitreous Society (JRVS). Methods, Intervention, or Testing An online questionnaire on OCTA terminology in retinal vascular diseases was sent to members of The Retina S...
Source
#1Andrew S H Tsai (NUS: National University of Singapore)H-Index: 8
Last. Chui Ming Gemmy Cheung (NUS: National University of Singapore)H-Index: 40
view all 10 authors...
Purpose:To examine the relationship between macular microvasculature parameters and functional changes in persons with diabetic retinopathy (DR).Methods:Cross-sectional study of 76 eyes with varying levels of DR. Optical coherence tomography angiography (OCTA) quantified superficial and deep perifov
Source
#1Mohammad H Bawany (UR: University of Rochester)H-Index: 1
#2Li Ding (UR: University of Rochester)H-Index: 6
Last. Ajay E. Kuriyan (URMC: University of Rochester Medical Center)H-Index: 19
view all 6 authors...
Purpose To investigate the correlation between quantifiable vessel density, computed in an automated fashion, from ultra-widefield fluorescein angiography (UWFFA) images from patients with proliferative diabetic retinopathy (PDR) with visual acuity and macular thickness. Methods We performed a secondary analysis of a prospective randomized controlled trial. We designed and trained an algorithm to automate retinal vessel detection from input UWFFA images. We then used our algorithm to study the c...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.