Effects of a hypercaloric diet on β‐cell responsivity in lean healthy men

Summary Objective Insulin resistance and hyperinsulinaemia precede the onset of obesity‐induced DM 2. The early adaptation of the β‐cell during the initial phase of overfeeding and weight gain has only been partly elucidated. We studied the early changes in insulin clearance and β‐cell responsivity during a positive and negative energy balance in lean healthy men. Design We studied in nine healthy lean men [age, 37 (27–43) years; BMI , 23·6...