Differentiation of responses to allergenic and irritant compounds in mouse popliteal lymph node assay.
Abstract
The mouse popliteal lymph node assay (PLNA) has been proposed as an immunotoxicological test to predict allergenic chemicals. However, PLN response is also observed in association with non-specific activation induced by some irritants. We, therefore, examined the kinetics of the PLN cellularity indices of primary and secondary responses. Flow cytometric analysis was used to measure the proportions of T and B cells in PLN. Male ICR mice were...
Paper Details
Title
Differentiation of responses to allergenic and irritant compounds in mouse popliteal lymph node assay.
Published Date
Jan 1, 2000
Volume
25
Issue
2
Pages
131 - 136
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