USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer.

Volume: 34, Issue: 30, Pages: 3957 - 3967
Published: Jul 23, 2015
Abstract
The oncoprotein c-Myc is frequently overexpressed in many cancers and is essential for cancer cell proliferation. Ubiquitin-proteasome-dependent degradation is one of the main ways in which cells control c-Myc abundance at a post-translational level. However, the underlying mechanism by which c-Myc is directly deubiquitinated is not fully understood. In this study, by screening ubiquitin-specific proteases (USPs) that may regulate c-Myc...
Paper Details
Title
USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer.
Published Date
Jul 23, 2015
Journal
Volume
34
Issue
30
Pages
3957 - 3967
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