Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

Science56.90
Volume: 346, Issue: 6206, Pages: 256 - 259
Published: Oct 10, 2014
Abstract
Cancers are composed of populations of cells with distinct molecular and phenotypic features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung cancers has not been well studied. We applied multiregion whole-exome sequencing (WES) on 11 localized lung adenocarcinomas. All tumors showed clear evidence of ITH. On average, 76% of all mutations and 20 out of 21 known cancer gene mutations were identified in all regions of individual...
Paper Details
Title
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
Published Date
Oct 10, 2014
Journal
Volume
346
Issue
6206
Pages
256 - 259
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