Feasibility and Efficacy of Induction Docetaxel, Cisplatin, and 5-Fluorouracil Chemotherapy Combined With Cisplatin Concurrent Chemoradiotherapy for Nonmetastatic Stage IV Head-and-Neck Squamous Cell Carcinomas

Purpose To report the experience of treating selected fit patients with locally advanced head-and-neck squamous cell carcinoma with three cycles of induction TPF (docetaxel 75 mg/m2, cisplatin 75 mg/m2, 5-fluorouracil 750 mg/m2, Days 2–5) followed by concurrent three-weekly bolus cisplatin 100 mg/m2 chemoradiotherapy. Methods and Materials Between March 2006 and February 2010, 66 patients with nonmetastatic Stage IV head-and-neck squamous cell...