A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF
Abstract
Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates that the mitogen is a new member of the epidermal growth factor (EGF) family. This heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma cells and...
Paper Details
Title
A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF
Published Date
Feb 22, 1991
Journal
Volume
251
Issue
4996
Pages
936 - 939
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