Bioreducible polymersomes for intracellular dual-drug delivery

Stimuli-sensitive polymersomes, composed of amphiphilic block copolymers, have emerged as a promising nanocarrier for triggered release of anticancer drugs. In this study, we synthesized a bioreducible, amphiphilic triblock copolymer based on poly(ethylene glycol)-b-poly(lysine)-b-poly(caprolactone) bearing a disulfide bond (PEG-b-PLys-SS-PCL). Owing to its unique amphiphilicity, the copolymer formed self-assembled polymersomes (256 nm diameter)...