How subvisible particles become invisible—relevance of the refractive index for protein particle analysis

Volume: 102, Issue: 5, Pages: 1434 - 1446
Published: May 1, 2013
Abstract
The aim of the present study was to quantitatively assess the relevance of transparency and refractive index (RI) on protein particle analysis by the light-based techniques light obscuration (LO) and Micro-Flow Imaging (MFI). A novel method for determining the RI of protein particles was developed and provided an RI of 1.41 for protein particles from two different proteins. An increased RI of the formulation by high protein concentration and/or...
Paper Details
Title
How subvisible particles become invisible—relevance of the refractive index for protein particle analysis
Published Date
May 1, 2013
Volume
102
Issue
5
Pages
1434 - 1446
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