Control of neural circuit formation by leucine-rich repeat proteins

•Leucine-rich repeat (LRR) proteins regulate the development, function, and plasticity of excitatory and inhibitory synapses. •Postsynaptic LRR proteins interact with key presynaptic receptors to promote pre- and postsynaptic differentiation. •Distinct LRR proteins are expressed in different cell types in the central nervous system (CNS). •LRR protein dysfunction may disrupt the excitation/inhibition balance and contribute to neuropsychiatric...