The Late Effects Clinic in action : For survivors of childhood malignancy

Published on Jan 1, 2007in Acta Oncologica4.089
路 DOI :10.1080/02841860701426815
Belinda A. Campbell16
Estimated H-index: 16
(Peter MacCallum Cancer Centre),
Greg Wheeler14
Estimated H-index: 14
(Peter MacCallum Cancer Centre)
+ 2 AuthorsNatalie Goroncy2
Estimated H-index: 2
(Peter MacCallum Cancer Centre)
Sources
Abstract
Background. Long-term survivors of childhood malignancy are a newly emergent patient group with a unique but wide range of survivorship issues. There are rising demands for long-term, medical follow-up and social support for this potentially vulnerable group. These demands stem from improving survival rates and the progressively increasing incidence of late physical, psychological and social sequelae. Case-studies and Discussion. The ideal method to facilitate this long-term follow-up is unclear, and faces the problems of health-care system limitations coupled with the paucity of outcomes-based research to guide evidence-based, clinical practice. We discuss how the Late Effects Clinic operates in our institution: optimising the involvement of the multi-disciplinary medical and allied health care teams to meet the physical and psychological needs of long-term survivors, and to assist with the social issues surrounding survivorship. This model involves a co-operative team approach, thereby alleviating the s...
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2 Authors (Konsler Gk, Jones Gr)
References26
Newest
#1Kevin C. Oeffinger (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 89
#2Ann C. Mertens (UMN: University of Minnesota)H-Index: 58
Last. Leslie L. RobisonH-Index: 154
view all 13 authors...
Background Only a few small studies have assessed the long-term morbidity that follows the treatment of childhood cancer. We determined the incidence and severity of chronic health conditions in adult survivors. Methods The Childhood Cancer Survivor Study is a retrospective cohort study that tracks the health status of adults who received a diagnosis of childhood cancer between 1970 and 1986 and compares the results with those of siblings. We calculated the frequencies of chronic conditions in 1...
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#1Noreen M. AzizH-Index: 26
#2Kevin C. Oeffinger (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 89
Last. Alicia J. Turoff (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
view all 4 authors...
BACKGROUND. The objective of this study was to provide a detailed description of comprehensive long-term follow-up (LTFU) programs for pediatric cancer survivors. METHODS. Program directors from 24 comprehensive LTFU programs in the U.S. and Canada completed a 6-page survey that provided details in 5 categories: description of the program, perceived benefits and strengths of the program, barriers to the development and use of the program, methods to improve the program, and an ideal model of car...
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#2Jozef H.A.M. Verbeek (Cochrane Collaboration)H-Index: 1
Last. Franciscus J.H. van DijkH-Index: 1
view all 3 authors...
A range of late effects is associated with the survival of childhood cancer, including problems with employment. The purpose of this metaanalysis was to assess the risk of unemployment of adult survivors of childhood cancer compared with healthy controls and to explore prognostic factors. A literature search of studies published between 1966 and January 2006 was conducted using the databases of MedLine, CINAHL, EMBASE, ClinPSYCH, PsycINFO, and OSHROM. The authors synthesized data using a random ...
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Children and adolescents who have survived childhood cancer are vulnerable to late effects of their disease and treatment experience, including both physical and psychological sequelae. The neurodevelopmental (ND) sequelae (e.g., difficulties with attention, memory, information processing, and other executive functions) faced by children surviving central nervous system (CNS) cancers or CNS treatments can have a range of effects on their psychological adjustment and quality of life as they reint...
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#1Roderick Skinner (RVI: Royal Victoria Infirmary)H-Index: 38
#2W. Hamish B. Wallace (Royal Hospital for Sick Children)H-Index: 52
Last. Gill Levitt (GOSH: Great Ormond Street Hospital)H-Index: 37
view all 3 authors...
Summary Substantial improvements in survival after treatment for malignant disease in childhood are leading to a rapidly increasing number of long-term survivors, many of whom are now adults. However, late chronic adverse effects of treatment are common, and have potentially severe effects on survivors' future physical, cognitive, or psychosocial health. The aim of long-term follow-up is to facilitate timely diagnosis and appropriate management of late adverse effects, thereby reducing the frequ...
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#4Jillian R. Mann (Boston Children's Hospital)H-Index: 28
Many survivors of childhood cancer have significant health problems due to their illness or treatment. This population-based study examines the number of long-term survivors, their disabilities and consequent long-term care needs. Survival rates for children diagnosed with cancer between 1960 and 1999 in the West Midlands, United Kingdom (UK), were used to estimate future long-term survivor numbers. Treatment and late effects data on a cohort of patients surviving for more than 5 years were used...
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#1Debra L. Friedman (UW: University of Washington)H-Index: 63
#2David R. Freyer (MSU: Michigan State University)H-Index: 38
Last. Gill LevittH-Index: 37
view all 3 authors...
With improvements in therapy for childhood cancer, the expectation that most childhood cancer patients will survive and enter adulthood is a reality. There is clear evidence that survivors are at risk for adverse health-related long-term sequelae associated with their cancer and its treatment, requiring appropriate health care resources. What is less clear is how this health care should optimally be delivered. We review the functional and operational needs for long-term follow-up for childhood c...
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#1Wendy Landier (City of Hope National Medical Center)H-Index: 40
#2W. Hamish B. Wallace (Royal Hospital for Sick Children)H-Index: 52
Last. Melissa M. Hudson (St. Jude Children's Research Hospital)H-Index: 102
view all 3 authors...
Cancer and its treatment predispose childhood cancer survivors to chronic or late occurring health problems that may not become clinically significant until many years after therapy. Frequently, long-term survivors of childhood cancer report late cancer-related effects that diminish quality of life and increase the risk of early mortality. Risk-based health care that involves a personalized plan for surveillance, screening, and prevention is recommended to reduce cancer-related morbidity in chil...
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#1Melissa M. Hudson (St. Jude Children's Research Hospital)H-Index: 102
With contemporary therapy, the majority of children and adolescents who are diagnosed with cancer will be cured. However, curative therapy predisposes to adverse health outcomes that affect the long-term survivor's quality of life and increase the risk of early mortality. Recognition of the adverse effects of cancer treatment on growth and development, vital organ function, fertility and reproduction, and secondary carcinogenesis has been the stimulus for the development of risk-adapted treatmen...
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#1Maru Barrera (U of T: University of Toronto)H-Index: 51
#2Amanda K. Shaw (Health Canada)H-Index: 5
Last. Lisa Pogany (Health Canada)H-Index: 14
view all 5 authors...
BACKGROUND The objectives of this study were to compare educational and social outcomes for young survivors of childhood cancer with a population control group of individuals who were never diagnosed with cancer and to identify risk and protective factors for these outcomes. METHODS In this multicenter, Canadian, retrospective cohort study, 800 survivors age 17 years or younger were matched by age and gender with a group of 923 control participants. Using a mailed survey that was completed by pa...
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Cited By3
Newest
#1Belinda A. Campbell (Peter MacCallum Cancer Centre)H-Index: 16
#2A. Lasocki (Peter MacCallum Cancer Centre)
Last. Greg Wheeler (Peter MacCallum Cancer Centre)H-Index: 14
view all 12 authors...
Abstract Aims Radiation-induced cavernomas (RIC) are common late toxicities in long-term survivors of malignancy following cerebral irradiation. However, the natural history of RIC is poorly described. We report the first series of long-term surveillance of RIC using modern magnetic resonance imaging (MRI) including highly sensitive susceptibility-weighted imaging (SWI). The aims of this research were to better characterise the natural history of RIC and investigate the utility of MRI-SWI for sc...
Source
#1Eva Koo (University of Melbourne)H-Index: 1
#2Michael A. Henderson (University of Melbourne)H-Index: 67
Last. Anita R. Skandarajah (University of Melbourne)H-Index: 15
view all 4 authors...
AIMS Survivors of childhood, adolescent, and young adulthood malignancies have an increased risk of subsequent primary malignancies, particularly after exposure to therapeutic radiation. This study aims to evaluate the mode of surveillance and surveillance compliance, incidence and mode of detection of breast cancer, breast cancer phenotype, and outcomes after radiation-associated breast cancer (RBC) in a late-effects cohort. METHODS Women exposed to therapeutic radiation attending the late effe...
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#1Lori Chait-Rubinek (ND: University of Notre Dame)H-Index: 1
#2Justin A. Mariani (Alfred Hospital)H-Index: 23
Last. Belinda A. Campbell (Peter MacCallum Cancer Centre)H-Index: 16
view all 8 authors...
Long-term survivors of childhood, adolescent and young adult (AYA) malignancies with past exposure to potentially cardiotoxic treatments are at risk of peripartum cardiac dysfunction. Incidence and risk factors for peripartum cardiac dysfunction and maternal cardiac outcomes in this population were investigated. Eligible long-term survivors were aged <30 years at cancer diagnosis, with 鈮1 pregnancy occurring 鈮5 years after diagnosis. 鈥淧eripartum鈥 cardiac events were defined as occurring within p...
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