Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems

Background and purpose Genetic thrombophilic conditions such as those associated with Factor V Leiden (FVL) and the prothrombin mutant (PT G20210A) have been identified as risk factors for cerebral venous thrombosis (CVT). Recently, a single nucleotide polymorphism (SNP) of the thrombin activatable fibrinolysis inhibitor (TAFI G–438A) has been shown to be associated with lower TAFI levels and to decrease the risk for peripheral venous...