Ketone bodies as signaling metabolites
Volume: 25, Issue: 1, Pages: 42 - 52
Published: Jan 1, 2014
Abstract
Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent findings support a model in which βOHB functions to link the environment, in this case the diet, and gene expression via chromatin modifications. We...
Paper Details
Title
Ketone bodies as signaling metabolites
Published Date
Jan 1, 2014
Volume
25
Issue
1
Pages
42 - 52
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