Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis
Abstract
The cholinergic anti-inflammatory pathway is an efferent vagus nerve-based mechanism that regulates immune responses and cytokine production through α7 nicotinic acetylcholine receptor (α7nAChR) signaling. Decreased efferent vagus nerve activity is observed in inflammatory bowel disease. We determined whether central activation of this pathway alters inflammation in mice with colitis and the mediating role of a vagus nerve-to-spleen circuit and...
Paper Details
Title
Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis
Published Date
Mar 1, 2014
Journal
Volume
7
Issue
2
Pages
335 - 347
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