Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
Abstract
The manner in which insulin resistance impinges on hepatic mitochondrial function is complex. Although liver insulin resistance is associated with respiratory dysfunction, the effect on fat oxidation remains controversial, and biosynthetic pathways that traverse mitochondria are actually increased. The tricarboxylic acid (TCA) cycle is the site of terminal fat oxidation, chief source of electrons for respiration, and a metabolic progenitor of...
Paper Details
Title
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver
Published Date
Jun 1, 2012
Journal
Volume
53
Issue
6
Pages
1080 - 1092
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Notes
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