Synthesis and Evaluation of Cleistanthin A Derivatives as Potent Vacuolar H⁺‐ATPase Inhibitors

Twelve new glycosides and alkane derivatives of cleistanthin A were designed and synthesized. Their in vitro antiproliferative activity was investigated against HCT ‐116, HepG2, A549, Hela tumor cell lines and HEK 293 cell by MTT assay. Most of these compounds displayed antiproliferative effects on four cancer cells at submicromolar concentration, but they were less potent than cleistanthin A Moreover, they showed no antiproliferative effects on...