Smad-dependent and Smad-independent pathways in TGF-beta family signalling.

Nature64.80
Volume: 425, Issue: 6958, Pages: 577 - 584
Published: Oct 9, 2003
Abstract
Transforming growth factor-beta (TGF-beta) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-beta signalling, the Smad proteins, are activated by receptors and translocate into the nucleus, where they regulate transcription. Although this pathway is inherently simple, combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and...
Paper Details
Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
Published Date
Oct 9, 2003
Journal
Volume
425
Issue
6958
Pages
577 - 584
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