Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI‐ceruloplasmin
Abstract
Ferroportin (Fpn), a ferrous iron Fe(II) transporter responsible for the entry of iron into plasma, is regulated post-translationally through internalization and degradation following binding of the hormone hepcidin. Cellular iron export is impaired in mice and humans with aceruloplasminemia, an iron overload disease due to mutations in the ferroxidase ceruloplasmin (Cp). In the absence of Cp Fpn is rapidly internalized and degraded. Depletion...
Paper Details
Title
Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI‐ceruloplasmin
Published Date
Jun 20, 2007
Journal
Volume
26
Issue
12
Pages
2823 - 2831
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