Mesenchymal stromal cells: a key player in ‘innate tolerance’?

Summary The existence of a mesenchymal stromal cell ( MSC ) population with the main property of physically supporting parenchymal tissues has long been recognized in virtually all organs. However, it was only recently that MSC have been identified as playing a novel role in modulating inflammation. It has been extensively documented that, under particular circumstances, MSC potently impair virtually all cells of the immune system, including...