A comparison of the CHO/HGPRT+ and the L5178Y/TK+/? mutation assays using suspension treatment and soft agar cloning: Results for 10 chemicals
Abstract
The mouse lymphoma assay (MLA) and Chinese hamster ovary (CHO) cell assay are sensitive indicators of mutagenicity. The CHO assay has been modified technically to permit treatment in suspension and soft agar cloning comparable to the MLA. This methodology eliminates the risk of metabolic cooperation and the trauma of trypsinization. In addition, a larger population of cells can be treated and cloned for mutant selection. In order to compare the...
Paper Details
Title
A comparison of the CHO/HGPRT+ and the L5178Y/TK+/? mutation assays using suspension treatment and soft agar cloning: Results for 10 chemicals
Published Date
Jan 1, 1993
Journal
Volume
9
Issue
3
Pages
243 - 257
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