Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients

Sirtuins (SIRTs) are master metabolic regulators with protective roles against obesity and obesity-associated metabolic disorders, including non-alcoholic fatty liver disease (NAFLD) and type-2 diabetes. We aimed to ascertain whether there is a relationship between serum SIRT1 and liver steatosis severity in obese patients. Seventy-two obese patients (BMI ≥ 30 kg/m2), 18 males and 54 females, mean age 39.66 ± 12.34 years, with ultrasonographic...