Secreted Versus Membrane-anchored Collagenases RELATIVE ROLES IN FIBROBLAST-DEPENDENT COLLAGENOLYSIS AND INVASION

Volume: 284, Issue: 34, Pages: 23001 - 23011
Published: Aug 21, 2009
Abstract
Fibroblasts degrade type I collagen, the major extracellular protein found in mammals, during events ranging from bulk tissue resorption to invasion through the three-dimensional extracellular matrix. Current evidence suggests that type I collagenolysis is mediated by secreted as well as membrane-anchored members of the matrix metalloproteinase (MMP) gene family. However, the roles played by these multiple and possibly redundant, degradative...
Paper Details
Title
Secreted Versus Membrane-anchored Collagenases RELATIVE ROLES IN FIBROBLAST-DEPENDENT COLLAGENOLYSIS AND INVASION
Published Date
Aug 21, 2009
Volume
284
Issue
34
Pages
23001 - 23011
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