The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference
Abstract
Arterivirus genus member Porcine reproductive and respiratory syndrome virus (PRRSV) causes an economically devastating disease, recently exacerbated by the emergence of highly pathogenic strains (HP-PRRSV). Within the nonstructural protein 2 of PRRSV is a deubiquitinating enzyme domain belonging to the viral ovarian tumor (vOTU) protease superfamily. vOTUs, which can greatly vary in their preference for their host ubiquitin (Ub) and Ub-like...
Paper Details
Title
The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference
Published Date
Apr 1, 2014
Journal
Volume
454-455
Pages
247 - 253
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