Thrombophilia in Patients With Retinoblastoma Receiving Ophthalmic Artery Chemosurgery

Published on Dec 1, 2012in Archives of Ophthalmology
· DOI :10.1001/ARCHOPHTHALMOL.2012.2284
Jasmine H. Francis22
Estimated H-index: 22
,
Y. Pierre Gobin46
Estimated H-index: 46
+ 5 AuthorsDavid H. Abramson79
Estimated H-index: 79
Sources
Abstract
References8
Newest
#1Jasmine H. Francis (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 22
#2Y. Pierre Gobin (NewYork–Presbyterian Hospital)H-Index: 46
Last. David H. Abramson (Cornell University)H-Index: 79
view all 7 authors...
Purpose Carboplatin administered systemically or periocularly can result in dramatic and prompt regression of retinoblastoma. However, both routes are rarely curative alone and have undesirable side effects. We aimed to assess the efficacy and toxicity of carboplatin +/− topotecan delivered by ophthalmic artery chemosurgery whereby chemotherapy is infused into the eye via the ophthalmic artery.
37 CitationsSource
#1David H. Abramson (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 79
#2Brian P. Marr (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 25
Last. Y. Pierre Gobin (Cornell University)H-Index: 46
view all 7 authors...
Massive intraocular hemorrhage developed in a child with advanced unilateral retinoblastoma after intrarterial treatment with Melphalan and Topotecan. The child tested positive for sickle cell trait. Sickle cell trait may predispose such children to slower vascular transit time, hypoxia, sickling and vascular occlusion caused by catheter induced decreased flow. Enucleation confirmed the ultrasound and selective angiogram findings in addition to a completely calcified tumor. Clinicians should be ...
10 CitationsSource
#1Olivia Wu (Glas.: University of Glasgow)H-Index: 25
#2Lindsay RobertsonH-Index: 7
Last. Ian A. GreerH-Index: 89
view all 11 authors...
BACKGROUND: Thrombophilia is a recognised risk factor for venous thromboembolism (VTE). However, the optimal management is unclear in terms of the need for and effectiveness of antithrombotic interventions, especially in high-risk patient groups, including the use of oral oestrogen preparations, pregnancy and major orthopaedic surgery. Clinicians have come under pressure to initiate thrombophilia testing on an increasing number of patients and thrombophilia screening in selected patient groups h...
410 CitationsSource
#1Selma Unal (Hacettepe University)H-Index: 11
#2Ali Varan (Hacettepe University)H-Index: 21
Last. Aytemiz Gürgey (Hacettepe University)H-Index: 32
view all 5 authors...
The purpose of this study was to evaluate inherited and acquired prothrombotic risk factors among children with malignancies who have thrombosis and emphasize the importance of inherited prothrombotic risk factors. Thirty-seven consecutive children with thrombosis and malignancy were included in this study. The patients were evaluated separately for time of development of thrombosis, insertion of a central venous line (CVL), history of l-asparaginase usage, and recent infections. Prothrombotic r...
26 CitationsSource
Central retinal vein occlusion is one of the commonest vascular diseases of the eye. The pathogenesis is multifactorial with both local factors and systemic diseases being aetiologically important. Many thrombophilic conditions have recently been identified and studies looking at their potential role in CRVO have been undertaken. The aim of this review is to critically appraise these studies as to date many have given conflicting results, making it far from clear what role thrombophilic conditio...
62 CitationsSource
#1Gary P. Siskin (Albany Medical College)H-Index: 20
#2Eric Reiner (Albany Medical College)H-Index: 1
Last. Gom Albons (Albany Medical College)H-Index: 1
view all 7 authors...
The activated clotting time (ACT) was investigated as a rapid, inexpensive, point-of-service screening test for coagulation abnormalities prior to catheter-based procedures. A total of 963 patients were screened by obtaining a history, standard coagulation profile, and activated coagulation time. The prevalence of normal patients (normal ACT and coagulation profile) was 94% (sensitivity = 91%; specificity = 27%). A normal ACT had a positive predictive value of 95%. The ACT was an acceptable scre...
5 CitationsSource
#1Isobel D. WalkerH-Index: 48
#2Mike GreavesH-Index: 25
Last. F. E. PrestonH-Index: 18
view all 3 authors...
237 CitationsSource
#1Ralf Knöfler (TUD: Dresden University of Technology)H-Index: 14
#2E. Siegert (TUD: Dresden University of Technology)H-Index: 1
Last. M. Kabus (TUD: Dresden University of Technology)H-Index: 3
view all 9 authors...
To evaluate the role of inherited thrombophilia in the development of central venous line (CVL)-related thrombosis, the following parameters were determined in 77 pediatric-oncologic patients with CVL: activated protein C (APC)-ratio, factor V (FV) G1691A and prothrombin G20210A mutation, protein C, protein S, antithrombin, coagulation factor XII, lipoprotein (a) and homocysteine. An inherited prothrombotic risk factor was found in 17 patients (23%). Four out of 14 patients with a single defect ...
58 CitationsSource
Cited By6
Newest
#1Christina Stathopoulos (UNIL: University of Lausanne)H-Index: 6
#2B Bartolini (CHUV: University Hospital of Lausanne)H-Index: 3
Last. Francis L. Munier (UNIL: University of Lausanne)H-Index: 61
view all 6 authors...
Purpose To identify risk factors for acute choroidal ischemia (ACI) after intra-arterial chemotherapy (IAC) for retinoblastoma. Design Retrospective cohort study. Participants Two hundred twenty patients (248 eyes) treated with IAC in Lausanne between November 2008 and September 2019 (665 procedures). All patients were evaluated on a monthly basis with fundus photography and fluorescein angiography before and after each IAC injection. Methods Acute choroidal ischemia, defined as any new choroida...
2 CitationsSource
#1Francis L. Munier (UNIL: University of Lausanne)H-Index: 61
#2Maja Beck-PopovicH-Index: 21
Last. Christina Stathopoulos (UNIL: University of Lausanne)H-Index: 6
view all 18 authors...
Abstract Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary aims. Historically, enucleation was the first successful therapeutic approach to decrease mortality, followed over 100 years ago by the first eye salvage attempts with radiotherapy. This led to the empiric delineation of a window for conservative management subject to a “state of metastatic grace” never t...
41 CitationsSource
#1Kelley J. Bohm (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
#2Y. Pierre Gobin (NewYork–Presbyterian Hospital)H-Index: 46
Last. David H. Abramson (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 79
view all 8 authors...
Methylenetetrahydrofolate reductase (MTHFR) genetic mutations and intra-procedural inhaled nitrous oxide (N2O) independently increase blood levels of homocysteine, a compound associated with thrombosis. Patients with MTHFR mutations who also receive N2O during ophthalmic artery chemotherapy (OAC) for retinoblastoma may have a heightened thrombotic risk. Single-center retrospective review of pediatric patients with advanced retinoblastoma who received OAC and developed choroidal infarcts. Four re...
1 CitationsSource
#2Paula Schaiquevich (CONICET: National Scientific and Technical Research Council)H-Index: 21
In recent years, there have been dramatic changes in the management of intraocular retinoblastoma. Intraocular retinoblastoma is a highly curable malignancy and current treatments are aimed to preserve vision while reducing the late effects such as treatment-induced secondary malignancies. The advent of intra-arterial chemotherapy changed the treatment paradigm from systemic treatment with chemotherapy to local treatment, and new questions emerged. While intra-arterial chemotherapy achieved enco...
28 CitationsSource
#1Y. Pierre Gobin (NewYork–Presbyterian Hospital)H-Index: 46
Intra-arterial chemotherapy (IAC) has become an essential technique in the treatment of advanced intra-ocular retinoblastoma. In this chapter, we describe our experience with 1000 intra-arterial infusions for treating 290 eyes with retinoblastoma in 229 children, median age 15 month. According to the Reese-Ellsworth classification, 83 % eyes were Group V; according to the International classification, 70 % eyes were Group D and 13 % eyes were Group E. Catheterizations were successful in 98.8 %. ...
3 CitationsSource
#1Jasmine H. Francis (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 22
#2Y. Pierre Gobin (NewYork–Presbyterian Hospital)H-Index: 46
Last. David H. Abramson (Cornell University)H-Index: 79
view all 7 authors...
Purpose Carboplatin administered systemically or periocularly can result in dramatic and prompt regression of retinoblastoma. However, both routes are rarely curative alone and have undesirable side effects. We aimed to assess the efficacy and toxicity of carboplatin +/− topotecan delivered by ophthalmic artery chemosurgery whereby chemotherapy is infused into the eye via the ophthalmic artery.
37 CitationsSource